Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells.
نویسندگان
چکیده
A new scanning probe-based microrheology approach is used to quantify the frequency-dependent viscoelastic behavior of both fibroblast cells and polymer gels. The scanning probe shape was modified using polystyrene beads for a defined surface area nondestructively deforming the sample. An extended Hertz model is introduced to measure the frequency-dependent storage and loss moduli even for thin cell samples. Control measurements of the polyacrylamide gels compare well with conventional rheological data. The cells show a viscoelastic signature similar to in vitro actin gels.
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ورودعنوان ژورنال:
- Physical review letters
دوره 85 4 شماره
صفحات -
تاریخ انتشار 2000